Visit Qingdao Haishi Hainuo Group Huimi Zhou

Louis Pasteur once said, "Although science knows no borders, scholars have their own country." Indeed, it is the responsibility of scientific researchers to be devoted to scientific research, but serving the country is the true destination of scientific researchers.
The world's hyaluronic acid looks at China, and China's hyaluronic acid looks at Shandong. Dr. Hui Mizhou, Chief Scientist of Qingdao Haishi Hainuo Group and Chairman of Qingdao Huinuode Biotechnology Co., Ltd., who has been tirelessly working in this field, has won respect for China and witnessed Chinese wisdom to the world with his profound and exquisite knowledge, outstanding wisdom, and tenacious and persistent attitude in the in-depth research and application of bioactive hyaluronic acid fragments with a molecular weight of 35kDa. On October 20, 2021, Huimi Zhou was successfully selected as a foreign academician of the Russian Academy of Natural Sciences.

The vast 'universe' seeks true knowledge

Many people say my name is awkward, and some people just call me Xiaohui, "Hui Mizhou said with a smile. He was born in 1959, when the world aerospace industry was booming. His father's relatives and friends looked through dictionaries and named him Mizhou, which means searching for the universe. For decades, Huimi Universe has been wandering in the vast universe of technology in search of true knowledge, perhaps it is fate in the underworld.

Huimi Zhou was born in a small town on the border of Inner Mongolia - Zhalantun City in Hulunbuir. The vast grasslands gave him a broad vision and resilient qualities, while the not wealthy family conditions in his childhood nurtured his spirit of abundance. Huimi Zhou's father is proficient in medical theory and has been exposed to his father's experience of treating and saving people since childhood, which has given him a natural affinity for medicine. He aspires to be admitted to Peking Union Medical College, the best medical university in China, when he grows up.

My college entrance examination score was fifth in Hailar City, but due to a 10 point difference, I missed Beijing Medical College. In 1979, Huimi Zhou was admitted to Harbin Medical University with a score 50 points higher than the admission line and became a medical student. The five-year journey of studying medicine has been long but fulfilling. Huimi Zhou has not given up his childhood dream. He knows that in order to achieve his ideals and aspirations, he must rely on learning to find a broader platform.

In 1984, after graduating from undergraduate studies, Hui Mizhou entered the coveted Peking Union Medical College to pursue a Master's degree in Medicine. He studied under the renowned medical experts Chi Zhisheng and Academician Shi Yifan, the founders of Chinese endocrinology, and began to gradually realize his life dream. Our endocrinology laboratory was established in the basement of the Institute of Basic Sciences by Dean Lu Zhaolin, who was one of the earliest to study abroad at that time. There, I learned laboratory techniques and research methods, and established a radioimmunoassay for detecting antidiuretic hormone with a sensitivity of 0.5pg/ml. Later, I studied in endocrinology clinical and outpatient settings. I remember when Dean Lu Zhaolin started to teach me clinical practice, I wrote down my first case three times, "Hui Mizhou recalled.

In the 1980s, the long closed doors of the country reopened, and young people with various dreams and wishes embarked on a journey abroad. Encouraged and guided by her mentor, Hui Mizhou went to the University of Toronto in Canada in 1989 to continue her doctoral studies in cell and molecular biology.

From a border town to the other side of the ocean

Science has no boundaries, and scientific research is an endless endeavor. Advancing is the lifelong theme of scientific researchers.

One hundred years ago, the discovery of insulin by the diabetes Institute of the University of Toronto was undoubtedly one of the greatest medical research in history, attracting researchers from all over the world to come here one after another to make significant contributions to the scientific community, including the figure of Huiqian.

In 1997, Hui Mizhou completed his doctoral and postdoctoral studies and research at the University of Toronto, and joined the world's largest biopharmaceutical company, Amgen, as a process scientist and Karajan, as a senior scientist and head of the process department. During this period, he has been working with Lin Fukun, the inventor of erythropoietin, and Tom BOONE, the inventor of leukopoietin. Lin Fukun, as a Chinese, once won the Nobel Prize in the pharmaceutical field, the Lasker Prize for Clinical Medicine. This event has brought great inspiration and inspiration to Huimiao: "The wisdom of Chinese people can also make the world admire and shock!"

In the field of biopharmaceuticals in the United States and Europe, everyone knows about the CHO cell line, which is the Chinese hamster ovary cell line, because the CHO cell line is the production tool for all recombinant protein drugs and antibody drugs. "Huimi Zhou explained with interest that it was not until later that they discovered the close relationship between Peking Union Medical College and CHO cell lines and biopharmaceuticals. In 1919, when Peking Union Medical College was established, it was not easy to obtain experimental mice, but there were many Chinese hamsters around Beijing. Experts used Chinese hamsters for the first time in Beijing to study pneumococcus. It was with the Chinese hamsters provided by Peking Union Medical College that American experts successfully cultivated Chinese hamster ovary cells

Despite being able to access the latest medical research results and have a comfortable and stable life abroad, Huimi Zhou still decided to return to his home country due to the lack of understanding from his peers! The most crucial aspect of the rejuvenation of the Chinese nation is the revival of technology. The happiness concept of anyone with lofty ideals is closely linked to serving the country and the people. "In 2008, Hui Mizhou resolutely left the United States where he had lived for 18 years and returned to his homeland.

Link the historical story of CHO cells

Promoting the implementation of scientific research achievements and rooting science in and benefiting the people is the natural mission of scientific and technological workers. There is a historical story linking CHO cells.

In 2008, I participated in the introduction of the world's biopharmaceutical industry giant Anjin Company to China. At that time, I did not know the story of CHO cells, and I was very sorry that I was unable to tell this story to the new president of Anjin Company. I was unable to invite him to visit my alma mater. Huimi Zhou began using CHO cells to produce alkaline phosphatase at the University of Toronto in 1990. Through more than 20 years of effort, he has been committed to using CHO cells to produce alkaline phosphatase and protein machine hyaluronidase PH20, completing a key link between Peking Union Medical College and the world's biopharmaceutical industry, which can be considered as making up for this regret.

After returning to China, Hui Mizhou successively served as the chief scientist in Harbin Pharmaceutical Group, China Pharmaceutical Group, Shanghai Huayi (Group) Company, the Academy of Military Medical Sciences and the Chinese Academy of Sciences, repaying the country and people with outstanding research results. He was the first in China to industrialize large-scale animal cell reactors with novel oxygen transfer mechanisms and practical GC gene expression systems and vaccine front-end reaction devices. He has also developed patented technology products such as multifunctional medical washing machines and blue oxygen water-cooled disinfectors, effectively solving the problem of sewage treatment reactions. His main research field is the study of clinical health food using alkaline phosphatase combined with B-HA for the treatment of endotoxins or inflammation related diseases. He has independently developed technologies including alkaline phosphatase function, gene expression technology rich in GC animal cells, oxygen drag gas-liquid mass transfer technology, ozone drag gas-liquid mass transfer technology, and production and application technology of bioactive hyaluronic acid B-HA. Its main areas of innovation and entrepreneurship include the production and application of torrent bioreactors, the production and application of blue oxygen anti-inflammatory disinfection appliances, the treatment of inflammatory skin diseases with bioactive hyaluronic acid B-HA, and the treatment of inflammatory pain, age-related diseases, and cancer with bioactive hyaluronic acid B-HA. Due to outstanding achievements and contributions, Huimi Zhou was awarded the "National May Day Labor Medal" in 2011 and was selected as a national science and technology innovation and entrepreneurship talent in 2012.

The stones from other mountains can be used to attack jade. The overseas returnee group has mostly gone through the learning stage in the early stage. With the rise of the national economy, they have continuously promoted the revival of China's science and technology with their lifelong learning. "Hui Mizhou said that he is an industrial scientist with independent intellectual property rights developed with the support of the Chinese government. After returning to China for more than 10 years, his research achievements and technological level have been at the forefront of the world.

The 'Blue Fair' made me connect with Qingdao

My entrepreneurship in Qingdao can also be attributed to the 'Blue Fair'. Through this conference, with the help of the Qingdao Organization Department and the Qingdao Human Resources and Social Security Bureau, I have established a close cooperative relationship with Qingdao Haishi Hainuo Group. Speaking of my experience of 'searching for relatives' in Qingdao since 2016, Huimi Zhou appeared particularly happy.

As a national key high-tech enterprise, Qingdao Haishi Hainuo Group respects science and emphasizes innovation, always putting scientific research and development in the first place of enterprise operation, and taking technological leadership and development as the first driving force for enterprise development. Huimi Zhou and Ma Zhaohui, the chairman of Haishi Hainuo Group Co., Ltd., have met as close as ever and have reached an agreement in the field of technological innovation, jointly establishing Qingdao Huinuode Biotechnology Co., Ltd. with the core business of research and development and production of small molecule hyaluronic acid (B-HA).

Haishi Hainuo Group has provided us with funding, office space, research laboratories, and factories, providing us with an excellent research environment. With the recommendation of Haishi Hainuo Group, Huimi Zhou was appointed as a special professor by Qingdao Agricultural University, fully leveraging his rich research experience and team's advantages in the field of animal medicine, promoting cooperation between animal medicine and food science, and promoting the school to continuously achieve new results in scientific research, discipline construction, scientific research achievement transformation, and young talent cultivation.

Speaking of which, Huimi Zhou touched the ground and talked about her experience of coming to Qingdao for the first time.

At that time, when my team members and I first came to Qingdao, we were really unfamiliar with the place and didn't even have a place to settle down, "Hui Mizhou said. The staff of the Qingdao Municipal Human Resources and Social Security Bureau's high-level talent service window learned about this situation and immediately contacted a pre packaged settlement site in Shibei District to solve the urgent problem for the team. This experience made Huimi Zhou feel the sincerity and warmth of Qingdao towards talents, and further strengthened his confidence in settling down in Qingdao.

Many people are curious about the different experiences that scientists have when starting a business? For this, Huimi Zhou told a little story.

During the outbreak, due to measures such as lockdown and isolation, the urgently needed liquid nitrogen equipment for the company could not be delivered in a timely manner, putting the cell line at risk of death and causing significant losses to the company. Huimi Zhou is so anxious that he waits for equipment at the border of the highway every day to handle and coordinate the entry of equipment into the city. He breathed a sigh of relief only after the liquid nitrogen freezing equipment was safely and successfully "revived" the cell line.

Being an industrial scientist is much more difficult than being a basic theoretical scientist. Engaging in scientific research only requires focusing on doing one's own thing well, while entrepreneurship requires dealing with various problems from all aspects. Through the life process of education at the University of Toronto, working in American companies, and local industrialization achievements, Huimi Zhou firmly believes that successful entrepreneurship is an important criterion for testing scientific research achievements.

Unlock new benefits of hyaluronic acid

Haishi Hainuo Group provides comprehensive support and promotion for Huimi Zhou's scientific research projects, allowing Huimi Zhou to have no worries and conduct research with more peace of mind. During the period of innovation and entrepreneurship in Qingdao, Huimi Zhou was highly praised by peers and experts for its research and industrialization achievements in the field of hyaluronic acid, and was successfully elected as a foreign academician of the Russian Academy of Natural Sciences.

The hyaluronic acid industry is one of the leading global medical industries in China, and Shandong Province accounts for about 80% of global sales of hyaluronic acid, "said Hui Mizhou." The efficacy or new efficacy of hyaluronic acid is related to its molecular weight, that is, hyaluronic acid and hyaluronic acid fragments with different molecular weights have different effects on the human body and tissue permeability. Further developing the new efficacy of hyaluronic acid is the key to expanding the hyaluronic acid market and increasing the output value of hyaluronic acid in China and Shandong.

Many great scientific inventions stem from chance, which is built on the foundation of diligence.

For a period of time, Huimi Zhou pondered over the new efficacy of hyaluronic acid every day. He accidentally discovered a type of hyaluronidase in women's breasts, which produced a recombinant human hyaluronidase PH20 cut hyaluronic acid fragment with a molecular weight of 35 kDa (also known as HA35 or B-HA). This 35 kDa hyaluronic acid fragment HA35 or B-HA injection can effectively treat inflammatory and neuropathic pain, as well as inflammation related diseases in clinical practice. On this basis, Huimizhou further developed a variety of disinfection products, medical devices and topical drugs, such as 35kDa hyaluronic acid fragment HA35 or B-HA nasopharyngeal spray, tooth brushing gel, skin gel, private care gel, hemorrhoid gel and eye drops. With professionalism and dedication, Huimi Zhou continuously unlocks new uses for hyaluronic acid, and its latest research results will greatly expand the scope of hyaluronic acid use, bringing good news to patients with inflammation and promoting the development of the hyaluronic acid industry in Shandong and even the whole country.

At present, Huinuode Biotechnology Co., Ltd. has applied for and obtained 10 patents related to bioactive hyaluronic acid (B-HA), achieving mass production of skincare products, food, daily necessities, disinfectants, and medical supplies with B-HA as the core. Among them, 7 invention patents have entered the substantive examination stage, 2 patents have been accepted, and multiple research results and patented technologies have been industrialized. The company's annual output value has reached 80 million yuan, creating good social and economic benefits.

At the beginning of the new year in 2022, Academician Huimi Zhou, who has entered the prime of his career as a scientist, is busy promoting and exchanging scientific research and technological achievements in Hainan, striving to expand the market, and planning to promote technological achievements to the international market. Life is only about 20000 days, and in this limited time, I am willing to hold a childlike heart and strive for China's scientific cause for the rest of my life. Turning scientific research achievements into products to benefit the motherland and the people is my lifelong pursuit, "said Huimi Zhou.